Diagnostic de l’intoxication digitalique et son traitement. Ferrero C. Author affiliations. Clinique universitaire de Médecine Interne, Hôpital Cantonal, Genève . Request PDF on ResearchGate | Intoxication digitalique en période néonatale: rôle de la déshydratation | Background Despite the great progress which has. Request PDF on ResearchGate | Intoxication digitalique massive. Traitement par hémoperfusion sur résine Amberlite XAD 4 | Haemoperfusion over amberlite.

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This report describes a fatal outcome to this problem despite aggressive medical management, including pervenous cardiac pacing and draws attention to deficiencies in current treatment of a serious problem.

Cardioversion and digitalis drugs: Post-countershock arrhythmias in untreated and digitalized dogs.

Support Center Support Center. Treatment of cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Table 2 Drug Interactions of Digitalis. Access to intoxicatlon full text of this article requires a subscription.

At higher concentrations, they increase the ventricular excitability. Finally, the anti digitalic antibodies can reverse the effect of digoxin in neutralizing its free fraction in serum and extracellular [5]. Am J Med Sci. The recommended therapeutical concentrations are of 0. The digibind study advisory panel. Personal information regarding our website’s visitors, including their identity, is confidential.

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Massive digoxin ingestion. Report of a case and review of currently available therapies.

Atropine administration must be taken into account in case of sinus bradycardia or atrioventricular block AV of the second and third degree to correct the effects of vagal stimulation.


The latter have a pejorative prognostic value. Headache, myalgia, asthenia are also frequent. Phenytoin diphenylhydantoin treatment of massive digoxin overdose.

These phenomena are related to an increase in the vagal tone and a decrease in the adrenergic one. Associated Data Supplementary Materials. Electrophysiological action At therapeutic concentrations, the digitalis glycosides decrease automaticity and slow atrioventricular conduction.

Pediatr Emerg Care Thus, the heart rate standardizes usually on a period of 30 minutes to 4 hours average delay of 90 minutes following the administration of the fragments of specific digoxin antibodies.

Acute digitalis intoxication digitaliqur into play the prognosis for survival is a rare complication in children, particularly in the neonatal period. Access to the PDF text. This decrease in neuro-hormonal activation represents a significant digitalqiue in the action of digitalis glycosides [2,3].

Cost-effectiveness analysis of the use of digoxin immune Digitaliquf ovine for treatment of digoxin toxicity.

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Disorders of impulse conduction and intoxicattion formation caused by hyperkalemia in man. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen. Clinical features and management of digitalis poisoning.

This text will be overwritten by jQuery. In fact, on one hand the antiporter uses the sodium gradient to move calcium to the extracellular space against his own concentration gradient. The dose depends on the quantity of digoxin present in the body.

John Libbey Eurotext – Médecine thérapeutique – Intoxication aiguë par la digoxine

Patients with severe renal impairment should be the subject of a prolonged follow up because it is not known with certainty if the inability to eliminate the antibody complex-digoxin may translate into a liberation of digoxin [6].


Interaction of epinephrine and ouabain on automaticity of canine Purkinje fibers. The high cost often limits the access to the hospital centers [7]. Recent studies set this margin to 0. Furthermore, despite therapeutical serum doses, an intoxication to the digoxin may appear in cases where the myocardial sensitivity is increased such as in hypothyroidism, advanced age, advanced heart diseases, myocardial ischemia, hypoxemia, electrolytic disorders and Acido-basic [].

The originality of this case has to do with the severity of the initial clinical picture, its total reversal with antibodies and the salting-out phenomena that followed.

J Pharmacol Exp Ther. Anti-digoxin antibodies in acute digitalis intoxication in an day-old newborn.

Digitalis intoxication shows itself in electrocardiogram ECG abnormalities that can lead to arrhythmia potentially fatal and in different signs and symptoms that are not specific. Journal page Archives Contents list. Abstract Despite being very familiar with digitalis, its use always asks for particular attention. Outline Masquer le plan. Voltage-time course and the effect of acetylcholine on atrial and nodal cells of the rabbit digitaloque.

The digoxin is administrated in a single daily take.