Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .

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Get free access to newly published articles Create a personal account or sign in to: Systemic corticosteroids or immunosuppressants were only temporarily necessary in 2 patients. Dermatology in General Medicine. Our data emphasize the importance of defining LET as a separate entity and demonstrate that this disease has been neglected in the literature since first described in Interestingly, the mainstay of treatment for LET, in the limited case reports and series that exist, is with antimalarial drugs, which our patient had already been taking for SLE.

Contin Educ Fam Physician.

Lupus Erythematosus Tumidus: A Unique Disease Entity

Important predisposing factors for cutaneous LE include:. The mean duration of the disease was 7. The skin involvement in SLE tends to mirror systemic involvement. Polymorphous light eruption is a frequent UV-induced dermatitis of papular, papulovesicular, or plaquelike appearance.

The clinical distinction between PLE and LET can be difficult; however, LET shows a much more delayed reaction after sun exposure, and healing of skin lesions takes much longer, even when sun exposure is avoided and a sun block is applied daily. Due to the rarity of cases reported, we emphasize the importance of detailed clinical examination supplemented by histopathological study since isolated examination may lead to underdiagnosing the disease.

Because of the rapid and effective improvement of the skin lesions after treatment with antimalarials, systemic corticosteroids or immunosuppressants were temporarily necessary in only 2 patients. In 3 patients, the dose had to be increased to 6—6. Support Center Support Center. Further systemic manifestations, such as renal, central nervous system, or lung involvement, have not yet manifested in any of the 40 patients during our study after up to 15 years.


Test areas were evaluated until specific lesions appeared for up to 4 weeks after the last irradiation. Received Jul 17; Accepted Oct Discoid LE is the most common form of chronic cutaneous LE.

Chronic cutaneous LE causes facial deformity and scarring. LE nonspecific cutaneous features are most often associated with SLE.

This case exemplifies the need for complete disease characterization, evidence-based treatment, and a multidisciplinary approach. Tumid lupus erythematosus Tumid lupus erythematosus also known as “lupus erythematosus tumidus” [1] is a rare, but distinctive entity in which patients present with edematous erythematous plaques, usually on the trunk. Lpuus her clinical presentation and histopathologic findings, a diagnosis of lupus erythematosus tumidus LET was made.

Cutaneous manifestations of lupus can be classified into specific subtypes — which include chronic cutaneous lupus erythematosus Tumodussubacute cutaneous lupus erythematosus SCLE and acute cutaneous lupus erythematosus ACLE — and nonspecific skin lesions — such as panniculitis, vasculitis and tumid lesions. Schmitt, et al, studied the characteristics of 44 patients with CLE, 24 of whom were diagnosed with LET, and found that LET had significantly decreased damage scores and increased mucin deposition, absent interface dermatitis, and alteration of hair follicles on histology when compared to other variants of CLE.

Collagen fibers were separated by mucin accumulation, which was confirmed by colloidal iron staining Figure 4. However, lypus our opinion, there is no doubt about LET being a separate entity that has been neglected in the literature since first being described in luupus The youngest patient was aged 9 months at initial diagnosis and had already had recurrent skin lesions for 10 years.

Cutaneous lupus erythematosus | DermNet NZ

Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression. The ANA fluorescence pattern was finely granular in tumisus except 1 case, where it was homogeneous. The clinical importance of this edematous, nonscarring, photosensitive type of CCLE as a distinct subset has been neglected in the literature and, since it has not always been considered as a separate entity, we suggest criteria to differentiate LET from PLE, Jessner’s lymphocytic infiltration of the skin, reticular erythematous mucinosis REMpseudolymphoma, SCLE, and other variants of CCLE.


Diagnostic features on biopsy are more likely to be found in LE-specific skin lesions than in LE-nonspecific cutaneous LE. All of the biopsy specimens showed a distinct subepidermal tumidud and mucin deposition between collagen bundles Figure 4.

Sign in to access your subscriptions Sign in to your personal account. A tumidux biopsy of right upper extremity revealing a superficial and deep periadnexal and interstitial infiltrate composed of lymphocytes, histiocytes, plasma cells, and a few scattered neutrophils.

One month later, she returned to clinic with a similar eruption, consistent with another episode of LET and was prescribed a low dose prednisone taper, 10mg for three weeks followed by 5mg for two weeks. Gougerot H, Bournier R. A year-old female patient presented with a complaint of lesion on the thorax for 4 months. Case Presentation A year-old caucasian woman with a one-year history of systemic lupus erythematosus SLE was referred to dermatology clinic for a persistent eruption of a rash on her face and arms.

Lupus tumidus is similar to Jessner lymphocytic infiltratein which diagnostic criteria for lupus are absent.

Anti-nuclear antibody, anti-Ro antibody, complete blood count and complement tests were tumiuds within the normal range. Jessner’s lymphocytic infiltration of the skin. Sex, age at onset, and duration of the disease at the time of the study are listed in Table 1.

A complete resolution of the skin lesions was seen after systemic therapy with antimalarials and, in some cases, with local corticosteroids or spontaneously without humidus treatment. Author information Copyright and License information Disclaimer. We performed an incisional biopsy and stained the sample with hematoxylin-eosin, colloidal iron and Ziehl-Neelsen.